Compare 1,000+ train, bus and airline operators on OmioWays to travel from Madrid to Brussels
Typical journey times and the lowest fares we found for each way to travel.
Journey times and fares come from Omio's route data, last checked on January 14, 2026. Prices change often and depend on your travel date. We may earn a commission if you book through our links, at no extra cost to you.
Good to know
- Over land, the quickest option is the train, at about 11h 37m.
- By train the journey takes about 11h 37m, with fares from €377; by bus it takes about 20h 40m, with fares from €43.
- Some connections include a change of train or bus. Omio shows the exact timetable and any changes before you book.
- The flight time covers the flight itself. Allow extra time to reach the airports and pass security, which can make ground transport just as fast on shorter routes.
Where to stay in Brussels
Hotels close to the centre of Brussels, from budget to luxury. Prices are typical nightly rates at our last check.
Budget
Mid-range
Upscale
LuxuryHotel prices come from Traveloka, last checked on February 4, 2026, and change with your dates. We may earn a commission if you book through our links, at no extra cost to you.
Ready to explore Brussels?
About Brussels
The heart of Europe blends Art Nouveau splendor with comic book culture and world-class chocolate. Brussels surprises with its Grand Place, quirky museums, and excellent beer bars.
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Return journey
More routes from Madrid
More routes to Brussels
Frequently asked questions
Quick answers based on current route data.
How long does it take to get from Madrid to Brussels?+
The quickest option is usually by plane, which takes about 2h 5m.
What is the cheapest way to get from Madrid to Brussels?+
The cheapest fares are usually by bus, from around €43. Prices depend on the date and how early you book.
Is there a train from Madrid to Brussels?+
Yes. Omio lists train connections from Madrid to Brussels, with a typical journey time of about 11h 37m. Some connections may include a change.
Is there a bus from Madrid to Brussels?+
Yes. Buses run from Madrid to Brussels, with a typical journey time of about 20h 40m and fares from around €43.
